{"id":61114,"date":"2024-08-22T15:41:15","date_gmt":"2024-08-22T08:41:15","guid":{"rendered":"https:\/\/www.dexagroup.com\/?post_type=sub-brand&#038;p=61114"},"modified":"2024-08-22T15:41:52","modified_gmt":"2024-08-22T08:41:52","slug":"zoledronic-acid-4-mg-100-ml-cairan-infus-id","status":"publish","type":"sub-brand","link":"https:\/\/www.dexagroup.com\/id\/produk\/zoledronic-acid-4-mg-100-ml-cairan-infus-id\/","title":{"rendered":"Zoledronic Acid 4 mg\/100 ml"},"content":{"rendered":"","protected":false},"author":12,"featured_media":61104,"template":"","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"brand_category":[5991],"brand_market":[5999],"sub_brand_manufacturer":[6017],"sub_brand_dosage_forms":[6599],"sub_brand_drug_classes":[],"sub_brand_marketer":[6085],"sub_brand_flavour":[],"sub_brand_warning_alcohol":[6193],"sub_brand_warning_machinery":[6201],"sub_brand_warning_pregnancy":[6206],"sub_brand_warning_lactation":[6214],"sub_brand_atc_1":[6226],"sub_brand_atc_2":[6296],"sub_brand_atc_3":[6508],"class_list":["post-61114","sub-brand","type-sub-brand","status-publish","has-post-thumbnail","hentry","brand_category-obat-generik-bermerek","brand_market-indonesia-id","sub_brand_manufacturer-fonko-international-pharmaceuticals","sub_brand_dosage_forms-cairan-infus","sub_brand_marketer-ferron-par-pharmaceuticals","sub_brand_warning_alcohol-konsultasikan-ke-dokter-anda","sub_brand_warning_machinery-konsultasikan-ke-dokter-anda","sub_brand_warning_pregnancy-tidak-direkomendasikan","sub_brand_warning_lactation-tidak-direkomendasikan","sub_brand_atc_1-m","sub_brand_atc_2-m05","sub_brand_atc_3-m05b"],"acf":{"sub-brand_grouping_basic_info":{"sub-brand_dosage_forms":6599,"sub-brand_flavour":false,"sub-brand_available_in":5999,"sub-brand_category":5991,"sub-brand_parent_brand":"","sub-brand_manufacturer":6017,"sub-brand_marketer":6085,"sub-brand_drug_class":false,"sub-brand_package":"Box, 1 botol plastik x 100 ml","sub-brand_atc_1":6226,"sub-brand_atc_2":6296,"sub-brand_atc_3":6508,"sub-brand_distribution_permit":"","sub-brand_website":"","sub-brand_product_leaflet":""},"sub-brand_indication":"<ul>\r\n \t<li>Pencegahan <em>skeletal-related events<\/em> (fraktur patologis, kompresi tulang belakang, radiasi atau operasi tulang, atau hiperkalsemia yang disebabkan tumor) pada pasien dengan kanker stadium lanjut\r\nyang melibatkan tulang.<\/li>\r\n \t<li>Pengobatan hiperkalsemia stadium lanjut (<em>hypercalcemia malignancy<\/em> - HCM).<\/li>\r\n<\/ul>","sub-brand_composition":"Zoledronic acid monohydrate setara dengan zoledronic acid 4 mg","sub-brand_grouping_warning":{"sub-brand_warning_alcohol":6193,"sub-brand_warning_machinery":6201,"sub-brand_warning_pregnancy":6206,"sub-brand_warning_lactation":6214},"sub-brand_precaution":"","sub-brand_contraindication":"","sub-brand_dosage":"<h3 class=\"box\">0-18 Tahun<\/h3>\r\nKeamanan dan efikasi zoledronic acid pada pasien anak belum diketahui.\r\n<h3 class=\"box\">18 Tahun ke Atas<\/h3>\r\n<strong>Pencegahan skeletal related events pada pasien kanker stadium lanjut yang melibatkan tulang<\/strong>\r\nDosis yang direkomendasikan adalah 4 mg zoledronic acid setiap 3-4 minggu. Pasien juga harus diberikan suplemen kalsium oral 500 mg dan vitamin D 400 IU setiap hari.\r\n\r\n<strong>Pengobatan hypercalcemia of malignancy<\/strong>\r\nDosis zoledronic acid yang direkomendasikan pada hiperkalsemia (kalsium serum setelah dikoreksi albumin \u226512,0 mg\/dl atau 3,0 mmol\/l) adalah infus tunggal 4 mg.\r\n<h3 class=\"box alt\">Pasien dengan Gangguan Fungsi Ginjal<\/h3>\r\n<strong>Hypercalcemia of malignancy (HCM)<\/strong>\r\nPengobatan zoledronic acid pada pasien dewasa dengan HCM yang juga memiliki gangguan fungsi ginjal berat harus mempertimbangkan antara risiko dan manfaat pengobatan. Tidak diperlukan penyesuaian dosis pada pasien HCM dengan kreatinin serum &lt;400 mikromol\/l atau &lt;4,5 mg\/dl.\r\n\r\n<strong>Pencegahan skeletal related events pada pasien kanker stadium lanjut yang melibatkan tulang<\/strong>\r\nKetika memulai pengobatan dengan zoledronic acid pada pasien dengan multipel mieloma atau metastasis lesi tulang dari tumor padat, kadar kreatinin serum dan bersihan kreatinin (Clcr) harus diukur. Zoledronic acid tidak direkomendasikan untuk pasien yang diketahui menderita gangguan fungsi ginjal berat (dengan Clcl &lt; 30 ml\/ menit). Pada pasien dewasa yang diketahui menderita metastasis tulang disertai gangguan fungsi ginjal ringan sampai sedang sebelum memulai terapi (dengan CrCl 30\u201360 ml\/menit), berikut dosis zoledronic acid yang direkomendasikan:\r\n\r\nCrCl &gt;60 : dosis zoledronic acid yang direkomendasikan 4,0 mg\r\nCrCl 50-60 : dosis zoledronic acid yang direkomendasikan 3,5 mg *\r\nCrCl 40-49 : dosis zoledronic acid yang direkomendasikan 3,3 mg *\r\nCrCl 30-39 : dosis zoledronic acid yang direkomendasikan 3,0 mg *\r\n\r\n* Dosis dihitung dengan asumsi target AUC 0,66 (mg.jam\/l) (ClCr= 75 ml\/menit).\r\n<h3 class=\"box alt\">Pasien dengan Gangguan Fungsi Hati<\/h3>\r\nKarena keterbatasan data klinis yang tersedia pada pasien dengan insufisiensi hati berat, maka tidak ada rekomendasi khusus yang dapat diberikan untuk kelompok pasien tersebut.\r\n<h3 class=\"box alt\">Cara Pemberian<\/h3>\r\nZoledronic acid hanya boleh diberikan kepada pasien oleh profesional kesehatan yang berpengalaman dalam pemberian bisfosfonat secara intravena.\r\n\r\nLarutan infus zoledronic acid adalah kemasan \"siap pakai\" dan tidak boleh diencerkan lebih lanjut atau dicampur dengan larutan infus lain kecuali untuk pasien dengan gangguan fungsi ginjal.\r\n\r\nZoledronic acid tidak boleh dicampur dengan kalsium atau kation divalen lain yang terkandung dalam larutan infus, seperti larutan Ringer Laktat dan harus diberikan sebagai larutan infus intravena tunggal dalam selang infus yang terpisah dari obat lain selama tidak kurang dari 15 menit. Pasien harus dijaga dalam keadaan terhidrasi dengan baik sebelum dan setelah pemberian zoledronic acid.","sub-brand_how_to_use":"","sub-brand_storage_method":"","sub-brand_drug_interactions":"","sub-brand_image_1":61106,"sub-brand_image_2":61108,"sub-brand_image_3":61110,"sub-brand_image_4":"","sub-brand_image_5":"","sub-brand_image_6":"","sub-brand_image_7":"","sub-brand_image_8":"","sub-brand_image_9":"","sub-brand_video":""},"publishpress_future_action":{"enabled":false,"date":"2026-08-25 01:06:19","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"brand_category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.dexagroup.com\/id\/wp-json\/wp\/v2\/sub-brand\/61114","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dexagroup.com\/id\/wp-json\/wp\/v2\/sub-brand"}],"about":[{"href":"https:\/\/www.dexagroup.com\/id\/wp-json\/wp\/v2\/types\/sub-brand"}],"author":[{"embeddable":true,"href":"https:\/\/www.dexagroup.com\/id\/wp-json\/wp\/v2\/users\/12"}],"version-history":[{"count":2,"href":"https:\/\/www.dexagroup.com\/id\/wp-json\/wp\/v2\/sub-brand\/61114\/revisions"}],"predecessor-version":[{"id":61116,"href":"https:\/\/www.dexagroup.com\/id\/wp-json\/wp\/v2\/sub-brand\/61114\/revisions\/61116"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.dexagroup.com\/id\/wp-json\/wp\/v2\/media\/61104"}],"wp:attachment":[{"href":"https:\/\/www.dexagroup.com\/id\/wp-json\/wp\/v2\/media?parent=61114"}],"wp:term":[{"taxonomy":"brand_category","embeddable":true,"href":"https:\/\/www.dexagroup.com\/id\/wp-json\/wp\/v2\/brand_category?post=61114"},{"taxonomy":"brand_market","embeddable":true,"href":"https:\/\/www.dexagroup.com\/id\/wp-json\/wp\/v2\/brand_market?post=61114"},{"taxonomy":"sub_brand_manufacturer","embeddable":true,"href":"https:\/\/www.dexagroup.com\/id\/wp-json\/wp\/v2\/sub_brand_manufacturer?post=61114"},{"taxonomy":"sub_brand_dosage_forms","embeddable":true,"href":"https:\/\/www.dexagroup.com\/id\/wp-json\/wp\/v2\/sub_brand_dosage_forms?post=61114"},{"taxonomy":"sub_brand_drug_classes","embeddable":true,"href":"https:\/\/www.dexagroup.com\/id\/wp-json\/wp\/v2\/sub_brand_drug_classes?post=61114"},{"taxonomy":"sub_brand_marketer","embeddable":true,"href":"https:\/\/www.dexagroup.com\/id\/wp-json\/wp\/v2\/sub_brand_marketer?post=61114"},{"taxonomy":"sub_brand_flavour","embeddable":true,"href":"https:\/\/www.dexagroup.com\/id\/wp-json\/wp\/v2\/sub_brand_flavour?post=61114"},{"taxonomy":"sub_brand_warning_alcohol","embeddable":true,"href":"https:\/\/www.dexagroup.com\/id\/wp-json\/wp\/v2\/sub_brand_warning_alcohol?post=61114"},{"taxonomy":"sub_brand_warning_machinery","embeddable":true,"href":"https:\/\/www.dexagroup.com\/id\/wp-json\/wp\/v2\/sub_brand_warning_machinery?post=61114"},{"taxonomy":"sub_brand_warning_pregnancy","embeddable":true,"href":"https:\/\/www.dexagroup.com\/id\/wp-json\/wp\/v2\/sub_brand_warning_pregnancy?post=61114"},{"taxonomy":"sub_brand_warning_lactation","embeddable":true,"href":"https:\/\/www.dexagroup.com\/id\/wp-json\/wp\/v2\/sub_brand_warning_lactation?post=61114"},{"taxonomy":"sub_brand_atc_1","embeddable":true,"href":"https:\/\/www.dexagroup.com\/id\/wp-json\/wp\/v2\/sub_brand_atc_1?post=61114"},{"taxonomy":"sub_brand_atc_2","embeddable":true,"href":"https:\/\/www.dexagroup.com\/id\/wp-json\/wp\/v2\/sub_brand_atc_2?post=61114"},{"taxonomy":"sub_brand_atc_3","embeddable":true,"href":"https:\/\/www.dexagroup.com\/id\/wp-json\/wp\/v2\/sub_brand_atc_3?post=61114"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}