Amikacin is indicated in the short-term treatment of serious infection due to susceptible strains of Gram-negative and Gram-positive bacteria.
- Septicemia (including neonatal sepsis)
- Serious infections of the respiratory tract
- Bone and joint infections
- Central nervous system infections (including meningitis)
- Skin and soft tissue infections
- Intra-abdominal infections (including peritonitis)
- Infections of the burns
- Postoperative infections (including post-vascular surgery)
- Serious complicated and recurrent urinary tract infections
Amikacin 500 mg
0 to 1 Year Old
Initial dose 10 mg/kg/day to be followed with 7.5 mg/kg every 12 hours.
1 to 18 Years Old
Children and older infants with normal renal function: 15 mg/kg/day divided into 2 or 3 equal doses.
18 Years Old and Above
500 mg twice daily. The maximum total dose for adults: 15 g.
The usual duration of treatment is 7 to 10 days. The total daily dose should not exceed 15 mg/kg/day or 1.5 g/day.
Patients with Impaired Renal Function
Daily dose may be reduced or prolonged intervals to avoid the drug accumulation. The initial dose is 7.5 mg/kg. Recommendation of the method to estimate dose in patients known or expected impaired renal function can be calculated by multiplying serum (in mg/100ml) creatinine concentration by 9 and the result is a dosage interval in hours.