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Cefrin powder for injection

Dexa Medica

Ingredients in every vial

Cefpirome 1 g

Each package contains

1 vial of 1 g

Dosage form

Powder for injection

Dosage formPowder for Injection

Flavour

None

W.H.O. classification

J01D
J01D

A.T.C. Level 1

Anatomical Main group

J - Antiinfectives for systemic use
J01D

A.T.C. Level 2

Therapeutic subgroup

J01 - Antibacterials for Systemic Use
J01D

A.T.C. Level 3

Pharmacological subgroup

J01D - Other Beta-Lactam Antibacterials in ATC

Available in

Indonesia

Warnings

Alcohol

CONSULT YOUR DOCTORSafety of this item for use with alcohol has not been established. Please consult your doctor.

Machinery

CONSULT YOUR DOCTORSafety of this item for use while operating heavy machinery has not been established. Please consult your doctor.

Pregnancy

NOT RECOMMENDEDThis item is not safe for use during pregnancy.

Lactation

NOT RECOMMENDEDThis item is not safe for use during lactation.

Indication

For infection treatment, whether before the causative organism is known or infections caused by bacterial organisms sensitive to cefpirome.
Lower respiratory tract infections
(bronchopneumonia, lobar pneumonia)
Complicated upper urinary tract infections
(pyelonephritis)
Complicated lower urinary tract infections
Skin and soft tissue infections
(cellulitis, skin abscess and infected wound)
Infections in neutropenic patients
Bacteremia / septicemia
Severe infections

Dosage

0 TO 12 YEARS OLD
Clinical data for children <12 years of age is insufficient. Therefore, cefpirome should not be used for this age group.

18 YEARS OLD AND ABOVE
The following dosages are recommended for moderate to severe infections in patients with normal renal function:

Complicated upper and lower urinary tract infections
– Unit dose: 1 g
– Dosage intervals: 12 hours
– Total daily dose: 2 g

Skin and soft tissue infections
– Unit dose: 1 g
– Dosage intervals: 12 hours
– Total daily dose: 2 g

Lower respiratory tract infections
– Unit dose: 1 to 2 g
– Dosage intervals: 12 hours
– Total daily dose: 2 to 4 g

Bacteremia/septicemia
– Unit dose: 2 g
– Dosage intervals: 12 hours
– Total daily dose: 4 g

Infections in neutropenic patients
– Unit dose: 2 g
– Dosage intervals: 12 hours
– Total daily dose: 4 g

Severe infections
– Unit dose: 2 g
– Dosage intervals: 12 hours
– Total daily dose: 4 g

For urinary tract and skin and soft tissue infections, the unit dose may be increased to 2 g in very severe cases.

65 YEARS OLD AND ABOVE
No adjustment is required unless renal impairment is present.

PATIENTS WITH IMPAIRED RENAL FUNCTION
Cefpirome is excreted principally by the kidney. The dose must therefore be reduced in patients with impaired renal function to compensate for the slower excretion. The recommended dosages are:

CrCl 20-50 ml/minute:
Initial dose 1 g, maintenance dose 0.5 g twice daily
Initial dose 2 g, maintenance dose 1 g twice daily

CrCl 5-20 ml/minute:
Initial dose 1 g, maintenance dose 0.5 g once daily
Initial dose 2 g, maintenance dose 1 g once daily

CrCl ˂5 ml/minute (in hemodyalysis patients)
Initial dose 1 g, maintenance dose 0.5 g once daily ± 0.25 g immediately after dialysis
Initial dose 2 g, maintenance dose 1 g once daily ± 0.5 g immediately after dialysis