Ceftazidime is used for the treatment of serious infections caused by susceptible, organisms as follows:
Septicemia, Bacteremia, Peritonitis, Meningitis, infections in immunosuppressed patients with hematological or solid malignancies, and in patients in intensive care units with specific problems, for example infected burns.
Lower respiratory tract infections
For example: Pneumonia, Bronchopneumonia, infected pleurisy, Empyema, lung abscess, infected Bronchiectasis, and lung infections in patients with Cystic Fibrosis.
Urinary Tract Infections
For example: acute and chronic Pyelonephritis, Pyelitis, Prostatitis, renal abscesses.
Skin and soft-tissue infections
For example: Erysipelas, abscesses, Cellulitis, infected burns and wounds, mastitis, skin ulcers.
Biliary and abdominal infections
For example: Cholangitis, Cholecystitis, Empyema of gallbladder, intra-abdominal abscesses, Peritonitis, Diverticulitis, pelvic inflammatory diseases.
Bone and joint infections
For example: Osteitis, Osteomyelitis, Septic arthritis, infected Bursitis.
Infections associated with hemo and peritoneal dialysis and with continuous ambulatory peritoneal dialysis (CAPD). Prior to initiation of ceftazidime therapy, appropriate specimens should be obtained for identification of the causative organism and in vitro susceptibility tests. Ceftazidime therapy may be started pending results of susceptibility tests, but should be discontinued if the organism is found to be resistant to the drug. When the causative organism is unknown, ceftazidime and concomitant therapy with other anti-infective agents may be indicated pending results of in vitro susceptibility tests. In severe or life-threatening infections or in immunocompromized patients, ceftazidime may be used concomitantly with other anti-infectives such as aminoglycosides, vancomycin, or clindamycin. The drugs should generally be administered separately.
Ceftazidime 1 g
0 to 2 Months Old
25 to 60 mg/kg/day given as two divided doses has proved to be effective.
2 Months to 18 Years Old
The usual dosage range for children aged over two months is 30 to 100 mg/kg/day, given as two or three divided doses. Doses up to 150 mg/kg/day (maximum 6 g daily) in three divided doses may be given to infected immunocompromized or fibrocystic children or children with meningitis.
18 Years Old and Above
1 to 6 g daily, may be given each dosage of 500 mg, 1 g or 2 g given 12 or 8-hourly by IV or IM injection.
In urinary infections and in many less serious infections:
500 mg or 1 g 12-hourly is usually adequate.
In the majority of infections:
1 g 8-hourly or 2 g 12-hourly should be given.
In very severe infections, especially in immunocompromized patients, including those with neutropenia:
2 g 8 or 12-hourly should be administered.
In fibrocystic adults with normal renal function who have pseudomonas lung infections:
High doses of 100 to 150 mg/kg/day as three divided doses should be used. In adults with normal renal function 9 g/day has been used safely.
Method of Administration
Ceftazidime is used parenterally, the dosage depending upon the severity, sensitivity, type of infection, age, weight, and renal function of the patient. Ceftazidime may be given intravenously or by deep intramuscular injection into a large muscle mass such as the upper outer quadrant of the gluteus maximus or lateral part of the thigh.
Patients with Impaired Renal Function
In patients with impaired renal function it is recommended that the dosage of ceftazidime should be adjusted or reduced.
Usual dose every 8-12 hours.
CrCl 31-50 ml/minute:
1.0 g every 12 hours.
CrCl 16-30 ml/minute:
1.0 g every 24 hours.
CrCl 6-15 ml/minute:
0.5 g every 24 hours.
CrCl <5 ml/minute:
0.5 g every 48 hours.
1.0 g after hemodialysis.
0.5 every 24 hours.