Cyclophosphamide 500 mg

Indonesia • Ferron Par Pharmaceuticals

Indication

For carcinoma and sarcoma:
Leukemia, lymphogranulomatosis, lymphosarcomas, retothelial sarcoma, multiple myeloma, mammary carcinoma, and ovarian carcinoma.

Composition

Cyclophosphamide monohydrate 500 mg

Package

1 vial of 500 mg

Dosage Forms

Powder for Injection

ATC Classification

L01A

Warning

Alcohol
Not Recommended
This item should not be used with alcohol.
Machinery
Caution
This item may not be safe for use while operating heavy machinery. Use with caution and after consultation with your doctor.
Pregnancy
Not Recommended
This item is not safe for use during pregnancy.
Lactation
Not Recommended
This item is not safe for use during lactation.

Dosage

0 to 18 Years Old

For continous treatment in adults and children:
3-6 mg/kg body weight daily (equivalent to 120-240 mg/m² body surface).

18 Years Old and Above

For continous treatment in adults and children:
3-6 mg/kg body weight daily (equivalent to 120-240 mg/m² body surface).

For intermittent treatment:
10-15 mg/kg body weight (equivalent to 400-600 mg/m² body surface) at intervals of 2-5 days.

For high dose intermittent treatment:
20-40 mg/kg body weight (equivalent to 800-1600 mg/m² body surface) and higher doses (e.g. for conditioning prior to bone marrow transplantation) at intervals of 21-28 days.

Administration

Cyclophosphamide monohydrate should only be administered by experienced oncologists. The dosage must be adapted to each patient individually.

Duration of therapy and intervals will depend on the indication, the applied combination chemotheraphy schedule and the patient’s general state of health, the laboratory parameters and the recovery of blood cell counts.

Attention should be paid to adequate hydration as well as to the administration of the uroprotector.

Patients with Hepatic and Renal Insufficiency

Severe hepatic or renal insufficiency requires a dose reduction. A dose reduction 25% for serum bilirubin from 3.1-5 mg/100 ml and of 50% for a glomerular filtration rate below 10 ml/minute is recommended.