Diabemin XR 1000 mg

Philippines • Dexa Medica

Indication

Treatment of type 2 diabetes mellitus in adults, particularly in overweight patients, when dietary management and exercise alone does not result in adequate glycemic control.

Metformin may be used as monotherapy or in combination with other oral antidiabetic agents, or with insulin.

Intensive glucose control with metformin as first-line therapy after diet failure in overweight type 2 diabetic patients has been shown to reduce diabetes complications.

Impaired glucose tolerance (IGT) for patients in whom lifestyle interventions (diet and exercise) have failed.

Composition

Metformin HCl 1.000 mg

Package

4 blisters of 15 extended-release tablets

Dosage Forms

Extended-release Tablet

ATC Classification

A10B

Warning

Alcohol
Not Recommended
This item should not be used with alcohol.
Machinery
Caution
This item may not be safe for use while operating heavy machinery. Use with caution and after consultation with your doctor.
Pregnancy
Not Recommended
This item is not safe for use during pregnancy.
Lactation
Not Recommended
This item is not safe for use during lactation.

Lactic acidosis
Lactic acidosis is a rare, but serious (high mortality in the absence of prompt treatment), metabolic complication that can occur due to metformin accumulation. Then incidence of lactic acidosis can and should be reduced by assessing also other associated risk factors such as poorly controlled diabetes, ketosis, prolonged fasting, excessive alcohol intake, hepatic insufficiency and any condition associated with hypoxia. It is characterized by acidotic dyspnea, vomiting, abdominal pain with muscle cramps, and/or general feeling of malaise with severe fatigue and hypothermia followed by coma. Lactic acidosis is a medical emergency. If metabolic acidosis is suspected, metformin should be discontinued and patients should be hospitalized immediately.

Renal function
As metformin is excreted mainly by the kidney, serum creatinine levels or creatinine clearance should be determined before initiating treatment (creatininemia <135 µmol/L in males and <110 µmol/L in females) and regularly thereafter: at least annually in patients with normal renal function and least two to four times a year in patients with creatinine at the lower limit of normal and in elderly subjects. Decreased renal function in elderly subjects is frequent and asymptomatic. Special caution should be exercised in situations where renal function may become impaired, for example in the elderly when initiating antihypertensive therapy or diuretic therapy and when starting therapy with a nonstreroidal anti-inflammatory.

Dosage

Metformin hydrochloride (DIABEMIN® XR) should generally be given once daily with the evening meal or with breakfast and evening meal (twice daily dosage) and should be started at a low dose, with gradual dose escalation. Subsequent dosage should be adjusted according to the patient’s therapeutic response, using the lowest possible effective dosage. Metformin hydrochloride (DIABEMIN® XR) must be swallowed whole and never crushed or chewed. Metformin hydrochloride (DIABEMIN® XR) should always be taken with food. This will avoid the patient having gastrointestinal discomfort.

Patients who have stopped the treatment must contact their doctor. In case the patients has forgotten to take metformin hydrochloride (DIABEMIN® XR), the next dose should be taken at the usual time. Do not double the dose of metformin unless otherwise prescribed by the doctor. It is normal that the tablet shells may be present in the feces and this is not linked with a decrease in therapeutic activity.