Glumin XR 1000

Indonesia • Ferron Par Pharmaceuticals


As mono or combined therapy
with sulphonylurea in patients with Non-insulin-dependent diabetes mellitus (type-2 diabetes) especially if overweight and whose blood glucose level cannot be controlled by diet alone.

As an adjuvant therapy
in insulin-dependent diabetic patients with hardly controlled symptoms.


Metformin HCL 1.000 mg


4 blisters of 15 extended-release caplets

Dosage Forms

Extended-release Caplet

ATC Classification



Not Recommended
This item should not be used with alcohol.
This item may not be safe for use while operating heavy machinery. Use with caution and after consultation with your doctor.
Not Recommended
This item is not safe for use during pregnancy.
Not Recommended
This item is not safe for use during lactation.


0 to 17 Years Old

Glumin XR should not be used in children.

17 Years Old and Above

Single dose Glumin XR 500, 750 and 1000 mg:
The initial dose of Glumin XR is one caplet 500 mg once a day. After 10 to 15 days the dose must be adjusted to the measurement of blood glucose. Enhancement dosage slowly improves gastrointestinal tolerance. The maximum dose is recommended is 4 Glumin XR 500 mg caplets a day.

If glycemic control is not achieved with administration of Glumin XR at a dose of 2,000 mg once a day, administration of Glumin XR 1,000 mg twice daily can be considered, both are given along with food. If glycemic control is still not achieved, patients can be given tablets standard metformin up to a maximum dose of 3000 mg a day.

In patients who have received metformin tablets, the initial dose of Glumin XR should be equivalent to the daily dosage of metformin immediate released tablet. In patients given metformin treatment with doses above 2000 mg daily, replacement with Glumin XR is not recommended.

If transfer from another oral antidiabetic agent is intended: discontinue the other agent and initiate Glumin XR at the dose indicated above.

Combination with insulin:
Metformin and insulin may be used in combination therapy to achieve better blood glucose control. The usual starting dose of Glumin XR is one 500 mg tablet once daily with the evening meal, while insulin dosage is adjusted on the basis of blood glucose measurements. After titration, switch to Glumin XR 1000 mg should be considered.

65 Years Old and Above

Due to the potential for decreased renal function in elderly patients, the metformin dosage should be adjusted based on renal function. Regular assessment of renal function is necessary.