Glumin XR 1000

Cambodia • Ferron Par Pharmaceuticals


Treatment of type 2 diabetes mellitus in adults, particularly in overweight patients, when dietary management and exercise alone does not result in adequate glycemic control. GLUMIN XR may be used as monotherapy or in combination with other oral antidiabetic agents, or with insulin.


Metformin HCL 1.000 mg


4 blisters of 15 extended-release caplets

Dosage Forms

Extended-release Tablet

ATC Classification



Not Recommended
This item should not be used with alcohol.
This item may not be safe for use while operating heavy machinery. Use with caution and after consultation with your doctor.
Not Recommended
This item is not safe for use during pregnancy.
Not Recommended
This item is not safe for use during lactation.



The usual starting dose is one caplet of GLUMIN XR 500 mg once daily.

After 10 to 15 days the dose should be adjusted on the basis of blood glucose measurements. A slow increase of dose may improve gastrointestinal tolerability. The maximum recommended dose is 4 caplets of GLUMIN XR 500 mg daily.

If glycemic control is not achieved on GLUMIN XR 2000 mg once daily, GLUMIN XR 1000 mg twice daily should be considered, with both doses being given with food. If glycemic control is still not achieved, patients may be switched to standard metformin caplets to a maximum dose of 3000 mg daily.

In patients already treated with metformin caplet, the starting dose of GLUMIN XR should be equivalent to the daily dose of metformin immediate release caplets. In patients treated with metformin at a dose above 2000 mg daily, switching to GLUMIN XR is not recommended.

If transfer from another oral antidiabetic agent is intended: discontinue the other agent and initiate GLUMIN XR at the dose indicated above.

Combination with insulin

Metformin and insulin may be used in combination therapy to achieve better blood glucose control. The usual starting dose of GLUMIN XR is one 500 mg caplet once daily with the evening meal, while insulin dosage is adjusted on the basis of blood glucose measurements. After titration, switch to GLUMIN XR 1000 mg should be considered.


Due to the potential for decreased renal function in elderly patients, the metformin dosage should be adjusted based on renal function. Regular assessment of renal function is necessary.