Granon 1mg/ml injection

Dexa Medica

Composition

Granisetron1 mg

Each Pack Contains

5 ampoules of 1 ml

Dosage Form

injection

Dosage formInjection

Flavor

None

W.H.O. Classification

A04A

Available In

Indonesia

Warning

Alcohol

CONSULT YOUR DOCTORSafety of this item for use with alcohol has not been established. Please consult your doctor.

Machinery

CONSULT YOUR DOCTORSafety of this item for use while operating heavy machinery has not been established. Please consult your doctor.

Pregnancy

NOT RECOMMENDEDThis item is not safe for use during pregnancy.

Lactation

NOT RECOMMENDEDThis item is not safe for use during lactation.

Indication

Granisetron is indicated for the prevention and treatment (control) of:
Acute and delayed nausea and vomiting associated with chemotherapy and radiotherapy
Postoperative nausea and vomiting

Dosage

18 YEARS OLD AND ABOVE
Chemotherapy induced nausea and vomiting (CINV)
a). Intravenous
Prevention:
1-3 mg (10-40 mcg/kg) as a slow intravenous injection (over 30 seconds) or as an intravenous infusion diluted in 20 to 50 ml infusion fluid and administered over 5 minutes, prior to the start of chemotherapy.

Treatment:
1-3 mg (10-40 mcg/kg) as a slow intravenous injection (over 30 seconds) or as an intravenous infusion diluted in 20 to 50 ml infusion fluid and administered over 5 minutes. Further treatment doses of granisetron may be administered, if required, at least 10 minutes apart. Maximum dose over 24 hours: 9 mg.

b). Intramuscular:
Prevention and treatment: 3 mg, 15 minutes prior to the start of chemotherapy. Two subsequent 3 mg doses of granisetron may be administered, if required, within a 24-hour period

Radiotherapy induced nausea and vomiting (RINV):
Prevention:
1-3 mg (10-40 mcg/kg) of granisetron should be administered either as a slow intravenous injection (over 30 seconds) or as an intravenous infusion diluted in 20 to 50 ml infusion fluid and administered over 5 minutes, prior to the start of radiotherapy.

Postoperative nausea and vomiting (PONV):
Prevention:
1 mg (10 mcg/kg) of granisetron should be administered as a slow intravenous injection (over 30 seconds) prior to induction of anesthesia.
Treatment:
1 mg (10 mcg/kg) of granisetron should be administered by slow intravenous injection (over 30 seconds).
Maximum dose for patients undergoing anesthesia for surgery: 3 mg in one day.

0 TO 18 YEARS OLD
Chemotherapy induced nausea and vomiting (CINV)
a). Intravenous:
10-40 mcg/kg body weight (up to 3 mg) as an intravenous infusion diluted in 10-30 ml infusion fluid and administered over 5 minutes prior to the start of chemotherapy. One additional dose may be administered within a 24 hour period if required. This additional dose should be administered until at least 10 minutes after the initial infusion.

b). Intramuscular:
Insufficient data.

Radiotherapy induced nausea and vomiting (RINV):
Insufficient data.

Postoperative nausea and vomiting (PONV):
Insufficient data.

ELDERLY
No dosage adjustment required.

PATIENTS WITH IMPAIRED RENAL FUNCTION
No dosage adjustment is required.

PATIENTS WITH HEPATIC IMPAIRMENT
No dosage adjustment required.