- The rapid control of hypertension during cardiac surgery
- Reducing blood pressure and maintain controlled hypotension during surgical procedures
- Controlling myocardial ischemia during and after surgery
- Unresponsive congestive heart failure secondary to acute myocardial infarction
- Unstable angina which is refractory to treatment with beta blockers and sublingual nitrates
Glyceryl Trinitrate 1 mg
0 to 18 Years Old
Safety and efficacy have not yet been established.
18 Years Old and Above
Recommended doses range:
10-200 mcg per minute, up to 400 mcg per minute may be necessary during some surgical procedures.
Starting dose: 25 mcg per minute for the control of hypertension, may be increased by increment of 25 mcg per minute at 5 minutes interval until the blood pressure is stabilized.
Treatment of perioperative myocardial ischemia:
Starting dose: 15-20 mcg per minute, with subsequent increment of 10-15 mcg per minute until the required effect is obtained.
Unresponsive congestive heart failure:
Starting dose: 20-25 mcg per minute, may be decreased to 10 mcg per minute or increased in steps of 20-25 mcg per minute every 15-30 minutes until the desired effect is obtained.
Initial dose: 10 mcg per minute, increment of 10 mcg per minute at 30 minutes intervals according to the needs of patient.
Glyceryl trinitrate solution is a concentrate which should be diluted prior to IV administration. The product is normally administered IV as an admixture using a suitable vehicle such as 5% dextrose or 0.9% sodium chloride injection.