Oxaliplatin 100 mg / 20 ml
Indonesia • Ferron Par Pharmaceuticals
Indication
Oxaliplatin in combination with 5-fluorouracil (5-FU) and folinic acid (FA) is indicated for:
- Adjuvant treatment of stage III (Duke’s C) colon cancer, after complete resection of primary tumor
- Treatment of metastatic colorectal cancer
Composition
Oxaliplatin 100 mg
Package
Dosage Forms
InjectionATC Classification
Warning
Dosage
Up to 18 Years
Not recommended.
18 Years Old and Above
In adjuvant setting:
The recommended dose for oxaliplatin is 85 mg/m² intravenously, repeated every 2 weeks for 12 cycles (6 months).
In treatment of metastatic colorectal cancer:
The recommended dose for oxaliplatin is 85 mg/m² intravenously repeated every 2 weeks.
Dosage given should be adjusted according to tolerability (see “warnings and precautions”).
Oxaliplatin should always be administered before fluoropyrimidines. Oxaliplatin is administered as a 2-6 hours intravenous infusion in 250 to 500 ml of 5% dextrose infusion to give a concentration not less than 0.2 mg/ml.
Oxaliplatin was mainly used in combination with continuous infusion 5-fluorouracil based regimens. For the two-weekly treatment schedule 5-fluorouracil regimens combining bolus and continuous infusion were used. In the event of extravasation, administration must be discontinued immediately.
Patients with Severe Renal Impairment
Oxaliplatin must not be administered in patients with severe renal impairment.