Palofer

Indonesia • Ferron Par Pharmaceuticals

Indication

  • The prevention of acute nausea and vomiting associated with highly emetogenic cancer chemotherapy.
  • The prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy.

Composition

Palonosetron HCl 0.25 mg

Package

1 vial of 5 ml

Dosage Forms

Injection

ATC Classification

A04A

Warning

Alcohol
Consult Your Doctor
Safety of this item for use with alcohol has not been established. Please consult your doctor.
Machinery
Caution
This item may not be safe for use while operating heavy machinery. Use with caution and after consultation with your doctor.
Pregnancy
Not Recommended
This item is not safe for use during pregnancy.
Lactation
Not Recommended
This item is not safe for use during lactation.

Dosage

Up to 18 Years

Use in patients younger than 18 is not recommended until further data is available.

18 Years Old and Above

250 micrograms palonosetron as single intravenous bolus.
Applied approximately 30 minutes before the start of chemotherapy. Palonosetron should be injected over 30 seconds.

Repeated dosing of palonosetron within a seven day interval is not recommended. The efficacy of palonosetron in the prevention of nausea and vomiting induced by highly emetogenic chemotherapy may be enhanced by the addition of corticosteroid administered prior to chemotherapy.

Elderly Patients

No dose adjustment is necessary for the elderly.

Patients with Hepatic Impairment

No dose adjustment is necessary for patients with impaired hepatic function.

Patients with Renal Impairment

No dose adjustment is necessary for patients with impaired renal function. No data are available for patients with end stage renal disease undergoing hemodialysis.

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