Sevodex

Indonesia • Dexa Medica

Indication

Sevoflurane is indicated for induction and maintenance of general anesthesia in adults and pediatric patients for inpatient and outpatient surgery.

Composition

Sevoflurane 250 ml

Package

1 bottle of 250 ml

Dosage Forms

Solution for Inhalation

ATC Classification

N01A

Warning

Alcohol
Consult Your Doctor
Safety of this item for use with alcohol has not been established. Please consult your doctor.
Machinery
Not Recommended
This item should not be used while operating heavy machinery.
Pregnancy
Caution
This item may not be safe for use during pregnancy. Use with caution and after consultation with your doctor.
Lactation
Caution
This item may not be safe for use during lactation. Use with caution and after consultation with your doctor.

Dosage

For All Ages

The concentration of sevoflurane being delivered from a vaporizer during anesthesia should be known. This may be accomplished by using a vaporizer calibrated specifically for sevoflurane. The administration of general anesthesia must be individualized based on the patient’s response.

Replacement of desiccated CO₂ absorbents:
When a clinician suspects that the CO₂ absorbent may be desiccated, it should be replaced. The exothermic reaction that occurs with sevoflurane and CO2 absorbents is increased when the CO₂ absorbent become desiccated, such as after an extended period of dry gas flow through the CO₂ absorbent canisters.

Pre-anesthetic medication:
Pre-medication should be selected according to the needs of the individual patient, and at the discretion of the anaesthetist.

Induction:
Sevoflurane has a non-pungent odor and does not cause respiratory irritability; it is suitable for mask induction in pediatrics and adults. Sevoflurane is given in concentrations of up to 5% in adults and 8% in children, with oxygen or a mixture of oxygen and nitrous oxide. Induction with sevoflurane is rapid (surgical anaesthesia in less than 2 minutes).

Maintenance:
Surgical levels of anesthesia can usually be achieved with concentrations of 0.5 – 3% sevoflurane with or without the concomitant use of nitrous oxide. Sevoflurane can be administered with any type of anesthesia circuit.

MAC (minimum alveolar concentration) values for adults and pediatric patients according to age:
0 – 1 month (Neonates are full-term gestational age. MAC in premature infants has not been determined.)
Sevoflurane in oxygen = 3.3%
Sevoflurane in 65% N₂O/35% O₂ = –

1 – <6 months
Sevoflurane in oxygen = 3.0%
Sevoflurane in 65% N₂O/35% O₂ = –

6 months – < 3 years
Sevoflurane in oxygen = 2.8%
Sevoflurane in 65% N₂O/35% O₂ = 2.0% (In 1 – < 3 year old pediatric patients, 60% N₂O/40% O₂ was used.)

3 – 12 years
Sevoflurane in oxygen = 2.5%
Sevoflurane in 65% N₂O/35% O₂ = –

25 years
Sevoflurane in oxygen = 2.6%
Sevoflurane in 65% N₂O/35% O₂ = 1.4%

40 years
Sevoflurane in oxygen = 2.1%
Sevoflurane in 65% N₂O/35% O₂ = 1.1%

60 years
Sevoflurane in oxygen = 1.7%
Sevoflurane in 65% N₂O/35% O₂ = 0.9%

80 years
Sevoflurane in oxygen = 1.4%
Sevoflurane in 65% N₂O/35% O₂ = 0.7%

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