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Volequin injection

Dexa Medica

Ingredients in every ml

Levofloxacin 5 mg

Each package contains

1 bottle of 100 ml

Dosage form

injection

Dosage formInjection

Flavour

None

W.H.O. classification

J01M
J01M

A.T.C. Level 1

Anatomical Main group

J - Antiinfectives for systemic use
J01M

A.T.C. Level 2

Therapeutic subgroup

J01 - Antibacterials for Systemic Use
J01M

A.T.C. Level 3

Pharmacological subgroup

J01M - Quinolone Antibacterials

Available in

Cambodia
Singapore

Warnings

Alcohol

CONSULT YOUR DOCTORSafety of this item for use with alcohol has not been established. Please consult your doctor.

Machinery

CAUTIONThis item may not be safe for use while operating heavy machinery. Use with caution and after consultation with your doctor.

Pregnancy

NOT RECOMMENDEDThis item is not safe for use during pregnancy.

Lactation

NOT RECOMMENDEDThis item is not safe for use during lactation.

Indication

Levofloxacin injection is indicated when intravenous administration offers a route of administration that is advantageous to the patient (e.g., patient cannot tolerate an oral dosage form). Levofloxacin is indicated for adults (≥18 years) in infections with susceptible microorganism, such as:
Acute maxillary sinusitis
Acute bacterial exacerbations of chronic bronchitis
Community-acquired pneumonia
Uncomplicated skin and skin structure infections
Complicated urinary tract infection
Acute pyelonephritis
Culture and susceptibility testing performed periodically during therapy will provide information about the continued susceptibility of the pathogens to the antimicrobial agent and also the possible emergence of bacterial resistance.

Dosage

18 TO 65 YEARS OLD
For the parenteral and oral dosage forms showing a bioequivalence, the same dosage can be used, usually for 7-14 days depending on severity of the disease.
Usual dosage in patients with normal renal function (creatinine clearance >80 ml/minute) is 250-500 mg once daily depending on type and severity of the infection and sensitivity of the pathogens.
It is usually possible to switch from initial intravenous treatment to the oral route after a few days, according to the condition of the patient.

65 YEARS OLD AND ABOVE
Elderly patients should receive the same dosage as normal adult patients.

PATIENTS WITH IMPAIRED HEPATIC FUNCTION
Patients with impaired hepatic function (but normal renal function) should receive the same dosage as normal adult patients.

PATIENTS WITH RENAL INSUFFICIENCY
Dosage in patients with renal insufficiency (creatinine clearance ≤50 ml/minute):
Renal clearance ≥50 ml/minute
No dosage adjustment required.

Renal clearance 20-49 ml/minute
Initial dosage: 500 mg.
Subsequent dosage: 250 mg per 24 hours.

Renal clearance 10-19 ml/minute
Initial dosage: 500 mg.
Subsequent dosage: 125 mg per 24 hours.

Hemodialysis
Initial dosage: 500 mg.
Subsequent dosage: 125 mg per 24 hours.

CAPD (Chronic Ambulatory Peritoneal Dialysis)
Initial dosage: 500 mg.
Subsequent dosage: 125 mg per 24 hours.

ADMINISTRATION
Levofloxacin hemihydrate injection should only be administered by slow intravenous infusion. The infusion time for 500 mg (100 ml) should not be less than 60 minutes and 250 mg (50 ml) should not be less than 30 minutes.

Protection from the light is not necessary during infusion time. Once the vial has been opened (rubber stopper perforated) the solution should be used immediately (within 3 hours) in order to prevent any bacterial contamination.