Demucin

There have been reports of severe skin reactions such as erythema multiforme, Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP) associated with the administration of bromhexine hydrochloride. Mostly these could be explained by the patient’s underlying disease and/or concomitant medication. In addition, during the early phase of Stevens-Johnson syndrome or TEN, a patient can first experience nonspecific influenza-like prodomes like e.g. fever, aching body, rhinitis, cough, and sore throat. Misled by these nonspecific influenza-like prodomes it is possible that a symptomatic treatment is started with a cough and cold medication.

If symptoms or signs of a progressive skin rash (sometimes associated with blisters or mucosal lesions) are present, bromhexine hydrochloride treatment should be discontinued immediately and medical advice should be sought.