Canderin 8

Indonesia • Dexa Medica

Indication

Hypertension
Treatment of patients with heart failure and impaired left ventricle systolic function (left ventricular ejection fraction ≤ 40%) when ACE-inhibitors are not tolerated.

Composition

Candesartan 8 mg

Package

3 blisters of 10 tablets

Dosage Forms

Tablet

ATC Classification

C09C

Warning

Alcohol
Consult Your Doctor
Safety of this item for use with alcohol has not been established. Please consult your doctor.
Machinery
Caution
This item may not be safe for use while operating heavy machinery. Use with caution and after consultation with your doctor.
Pregnancy
Not Recommended
This item is not safe for use during pregnancy.
Lactation
Not Recommended
This item is not safe for use during lactation.

Dosage

0 to 18 Years Old

The safety and efficacy of candesartan have not been established in children and adolescents (under 18 years).

18 to 65 Years Old

Dosage in hypertension:
The initial dose is 4 mg once daily. The dose should be adjusted according to response, with a maximum dose of 16 mg daily. The maximum effect is achieved within about 4 weeks after initiating therapy.

Dosage in heart failure:
The usual recommended initial dose is 4 mg once daily. Up-titration to the target dose of 32 mg once daily or the highest tolerated dose is done by doubling the dose at intervals of at least 2 weeks.

65 Years Old and Above

No initial dosage adjustment is necessary in elderly patients.

Administration

Candesartan should be taken once daily with or without food. Candesartan can be administered with other antihypertensive drugs.

Patients with Hepatic Impairment

Dosage in hypertension:
An initial dose of 2 mg once daily is recommended in patients with mild to moderate hepatic impairment. The dose may be adjusted according to response. There is no experience in patients with severe hepatic impairment.

Dosage in heart failure:
No initial dose adjustment is necessary in patients with mild to moderate hepatic impairment.

Patients with Renal Impairment

Dosage in hypertension:
No initial dosage adjustment is necessary in mild renal impairment. A lower initial dose of 2 mg once daily is suggested for patients with moderate and severe renal impairment. The dose may be adjusted according to response.

Dosage in heart failure:
No initial dose adjustment is necessary for patients with renal impairment.