Treatment of chronic hyperuricemia in conditions where urate deposition has already occurred (including a history, or presence of tophus, gouty arthritis and/or uric nephrolithiasis).
Febuxostat 40 mg
Under 18 Years Old
Safety and effectiveness have not been established.
18 Years Old and Above
The recommended oral dose of febuxostat is 80 mg once daily without regard to food. If serum uric acid is >6 mg/dl (357 μmol/l) after 2-4 weeks and risk factor modification has failed, febuxostat 120 mg once daily may be considered.
Febuxostat works sufficiently quickly to allow retesting of the serum uric acid after 2 weeks. The therapeutic target is to decrease and maintain serum uric acid below 6 mg/dl (357 μmol/l).
Gout flare prophylaxis of at least 6 months is recommended.
65 Years Old and Above
No dose adjustment is required in the elderly.