- The rapid control of hypertension during cardiac surgery.
- Reducing blood pressure and maintain controlled hypotension during surgical procedures.
- Controlling myocardial ischemia during and after surgery.
Unresponsive congestive heart failure secondary to acute myocardial infarction
Unstable angina which is refractory to treatment with beta blockers and sublingual nitrates
Glyceryl Trinitrate 1 mg
0 to 18 Years Old
Safety and efficacy have not yet been established.
18 Years Old and Above
Recommended doses range:
10-200 mcg per minute, up to 400 mcg per minute may be necessary during some surgical procedures.
Starting dose: 25 mcg per minute for the control of hypertension, may be increased by increment of 25 mcg per minute at 5 minutes interval until the blood pressure is stabilized.
Treatment of perioperative myocardial ischemia:
Starting dose: 15-20 mcg per minute, with subsequent increment of 10-15 mcg per minute until the required effect is obtained.
Unresponsive congestive heart failure:
Starting dose: 20-25 mcg per minute, may be decreased to 10 mcg per minute or increased in steps of 20-25 mcg per minute every 15-30 minutes until the desired effect is obtained.
Initial dose: 10 mcg per minute, increment of 10 mcg per minute at 30 minutes intervals according to the needs of patient.
Glyceryl trinitrate solution is a concentrate which should be diluted prior to IV administration. The product is normally administered IV as an admixture using a suitable vehicle such as 5% dextrose or 0.9% sodium chloride injection.