Granon 1
Indication
Granisetron is indicated for the prevention and treatment (control) of:
- Acute and delayed nausea and vomiting associated with chemotherapy and radiotherapy
- Postoperative nausea and vomiting
Composition
Granisetron 1 mg
Package
Dosage Forms
ATC Classification
Warning
Dosage
0 to 18 Years Old
Chemotherapy induced nausea and vomiting (CINV)
Intravenous:
10-40 mcg/kg body weight (up to 3 mg) as an intravenous infusion diluted in 10-30 ml infusion fluid and administered over 5 minutes prior to the start of chemotherapy. One additional dose may be administered within a 24 hour period if required. This additional dose should be administered until at least 10 minutes after the initial infusion.
Intramuscular:
Insufficient data.
Radiotherapy induced nausea and vomiting (RINV):
Insufficient data.
Postoperative nausea and vomiting (PONV):
Insufficient data.
18 Years Old and Above
Chemotherapy induced nausea and vomiting (CINV).
Intravenous:
- Prevention: 1-3 mg (10-40 mcg/kg) as a slow intravenous injection (over 30 seconds) or as an intravenous infusion diluted in 20 to 50 ml infusion fluid and administered over 5 minutes, prior to the start of chemotherapy.
- Treatment: 1-3 mg (10-40 mcg/kg) as a slow intravenous injection (over 30 seconds) or as an intravenous infusion diluted in 20 to 50 ml infusion fluid and administered over 5 minutes. Further treatment doses of granisetron may be administered, if required, at least 10 minutes apart. Maximum dose over 24 hours: 9 mg.
Intramuscular:
- Prevention and treatment: 3 mg, 15 minutes prior to the start of chemotherapy. Two subsequent 3 mg doses of granisetron may be administered, if required, within a 24-hour period
Radiotherapy induced nausea and vomiting (RINV):
- Prevention: 1-3 mg (10-40 mcg/kg) of granisetron should be administered either as a slow intravenous injection (over 30 seconds) or as an intravenous infusion diluted in 20 to 50 ml infusion fluid and administered over 5 minutes, prior to the start of radiotherapy.
Postoperative nausea and vomiting (PONV):
- Prevention: 1 mg (10 mcg/kg) of granisetron should be administered as a slow intravenous injection (over 30 seconds) prior to induction of anesthesia.
- Treatment: 1 mg (10 mcg/kg) of granisetron should be administered by slow intravenous injection (over 30 seconds).
Maximum dose for patients undergoing anesthesia for surgery: 3 mg in one day.
Elderly Patients
No dosage adjustment required.
Patients with Impaired Renal Function
No dosage adjustment is required.
Patients with Hepatic Impairment
No dosage adjustment required.