Granon 1

Indonesia • Dexa Medica

Indication

Granisetron is indicated for the prevention and treatment (control) of:

  • Acute and delayed nausea and vomiting associated with chemotherapy and radiotherapy
  • Postoperative nausea and vomiting

Composition

Granisetron 1 mg

Package

5 ampoules of 1 ml

Dosage Forms

Injection

ATC Classification

A04A

Warning

Alcohol
Consult Your Doctor
Safety of this item for use with alcohol has not been established. Please consult your doctor.
Machinery
Consult Your Doctor
Safety of this item for use while operating heavy machinery has not been established. Please consult your doctor.
Pregnancy
Not Recommended
This item is not safe for use during pregnancy.
Lactation
Not Recommended
This item is not safe for use during lactation.

Dosage

0 to 18 Years Old

Chemotherapy induced nausea and vomiting (CINV)

Intravenous:
10-40 mcg/kg body weight (up to 3 mg) as an intravenous infusion diluted in 10-30 ml infusion fluid and administered over 5 minutes prior to the start of chemotherapy. One additional dose may be administered within a 24 hour period if required. This additional dose should be administered until at least 10 minutes after the initial infusion.

Intramuscular:
Insufficient data.

Radiotherapy induced nausea and vomiting (RINV):
Insufficient data.

Postoperative nausea and vomiting (PONV):
Insufficient data.

18 Years Old and Above

Chemotherapy induced nausea and vomiting (CINV).

Intravenous:

  • Prevention: 1-3 mg (10-40 mcg/kg) as a slow intravenous injection (over 30 seconds) or as an intravenous infusion diluted in 20 to 50 ml infusion fluid and administered over 5 minutes, prior to the start of chemotherapy.
  • Treatment: 1-3 mg (10-40 mcg/kg) as a slow intravenous injection (over 30 seconds) or as an intravenous infusion diluted in 20 to 50 ml infusion fluid and administered over 5 minutes. Further treatment doses of granisetron may be administered, if required, at least 10 minutes apart. Maximum dose over 24 hours: 9 mg.

Intramuscular:

  • Prevention and treatment: 3 mg, 15 minutes prior to the start of chemotherapy. Two subsequent 3 mg doses of granisetron may be administered, if required, within a 24-hour period

Radiotherapy induced nausea and vomiting (RINV):

  • Prevention: 1-3 mg (10-40 mcg/kg) of granisetron should be administered either as a slow intravenous injection (over 30 seconds) or as an intravenous infusion diluted in 20 to 50 ml infusion fluid and administered over 5 minutes, prior to the start of radiotherapy.

Postoperative nausea and vomiting (PONV):

  • Prevention: 1 mg (10 mcg/kg) of granisetron should be administered as a slow intravenous injection (over 30 seconds) prior to induction of anesthesia.
  • Treatment: 1 mg (10 mcg/kg) of granisetron should be administered by slow intravenous injection (over 30 seconds).
    Maximum dose for patients undergoing anesthesia for surgery: 3 mg in one day.

Elderly Patients

No dosage adjustment required.

Patients with Impaired Renal Function

No dosage adjustment is required.

Patients with Hepatic Impairment

No dosage adjustment required.

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