Lepsio

Indonesia • Dexa Medica

Indication

Valproic acid may be used as sole or adjunctive therapy in the treatment of partial seizures (both elementary and complex) and absence seizures (petit mal seizures).

Composition

Valproic Acid 250 mg

Package

1 bottle of 100 ml

Dosage Forms

Syrup

ATC Classification

N03A

Warning

Alcohol
Consult Your Doctor
Safety of this item for use with alcohol has not been established. Please consult your doctor.
Machinery
Caution
This item may not be safe for use while operating heavy machinery. Use with caution and after consultation with your doctor.
Pregnancy
Consult Your Doctor
Safety of this item for use during pregnancy has not been established. Please consult your doctor.
Lactation
Caution
This item may not be safe for use during lactation. Use with caution and after consultation with your doctor.

Dosage

For All Ages

Lepsio is administered orally. The recommended initial dose is 15 mg/kg/day, increasing at one week intervals by 5 to 10 mg/kg/day, until seizures are controlled or side effects preclude further increases.

The maximum recommended dosage is 60 mg/kg/day. If the total daily dose exceeds 250 mg, it should be given in a divided regimen.

Pediatric Use

Hepatotoxicity appears to be more common in children, especially those under 2 years and those taking multiple antiepileptic drugs. The drug should be used with extreme caution and as single-agent therapy in such children, and the benefits of valproic acid therapy weighed against the risks.

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