Valproic acid may be used as sole or adjunctive therapy in the treatment of partial seizures (both elementary and complex) and absence seizures (petit mal seizures).
Valproic Acid 250 mg
For All Ages
Lepsio is administered orally. The recommended initial dose is 15 mg/kg/day, increasing at one week intervals by 5 to 10 mg/kg/day, until seizures are controlled or side effects preclude further increases.
The maximum recommended dosage is 60 mg/kg/day. If the total daily dose exceeds 250 mg, it should be given in a divided regimen.
Hepatotoxicity appears to be more common in children, especially those under 2 years and those taking multiple antiepileptic drugs. The drug should be used with extreme caution and as single-agent therapy in such children, and the benefits of valproic acid therapy weighed against the risks.