Prezinton

4 to 18 Years Old

Prevention and therapy of chemotherapy induced nausea and vomiting:
5 mg/m2 intravenously over 15 minutes immediately before chemotherapy, followed by 4 mg orally twice daily for 5 days.

18 to 65 Years Old

The treatment of postoperative nausea and vomiting:

• A single 4 mg dose by intramuscular or slow intravenous injection.

Prevention and therapy of chemotherapy induced nausea and vomiting:

• Highly emetogenic chemotherapy, e.g., cisplatin: Initially, ondansetron 8 mg by slow intravenous injection or by intravenous infusion over a period of at least 15 minutes immediately before treatment, followed by a continuous intravenous infusion of 1 mg per hour for up to 24 hours, or by a further two doses of 8 mg by slow intravenous injection or by intravenous infusion over at least 15 minutes four hours apart. Or may be followed with ondansetron 8 mg orally twice daily for up to 5 days.
• Less emetogenic chemotherapy, e.g. cyclophosphamide: Ondansetron 8 mg may be given as a slow intravenous injection or by intravenous infusion over a period of at least 15 minutes immediately before treatment, followed by 8 mg orally twice daily for up to 5 days.

65 Years Old and Above

Ondansetron is well tolerated in patients over 65 years without dosage adjustment, frequency and method of administration.

Patients with Renal Impairment

Do not require daily dose adjustment, frequency or drug administration.

Patients with Hepatic Impairment

The total daily dose of 8 mg ondansetron should not be exceeded.