Prezinton
Indication
Treatment and prevention of nausea and vomiting associated with chemotherapy, radiotherapy and surgery.
Composition
Ondansetron 2 mg
Package
2 ampoules of 4 ml
Dosage Forms
ATC Classification
A04A
Warning
Alcohol
Consult Your Doctor
Safety of this item for use with alcohol has not been established. Please consult your doctor.
Machinery
Safe if Prescribed
This item is safe for use while operating heavy machinery.
Pregnancy
Not Recommended
This item is not safe for use during pregnancy.
Lactation
Not Recommended
This item is not safe for use during lactation.
Dosage
4 to 18 Years Old
Prevention and therapy of chemotherapy induced nausea and vomiting:
5 mg/m2 intravenously over 15 minutes immediately before chemotherapy, followed by 4 mg orally twice daily for 5 days.
18 to 65 Years Old
The treatment of postoperative nausea and vomiting:
- A single 4 mg dose by intramuscular or slow intravenous injection.
Prevention and therapy of chemotherapy induced nausea and vomiting:
- Highly emetogenic chemotherapy, e.g., cisplatin: Initially, ondansetron 8 mg by slow intravenous injection or by intravenous infusion over a period of at least 15 minutes immediately before treatment, followed by a continuous intravenous infusion of 1 mg per hour for up to 24 hours, or by a further two doses of 8 mg by slow intravenous injection or by intravenous infusion over at least 15 minutes four hours apart. Or may be followed with ondansetron 8 mg orally twice daily for up to 5 days.
- Less emetogenic chemotherapy, e.g. cyclophosphamide: Ondansetron 8 mg may be given as a slow intravenous injection or by intravenous infusion over a period of at least 15 minutes immediately before treatment, followed by 8 mg orally twice daily for up to 5 days.
65 Years Old and Above
Ondansetron is well tolerated in patients over 65 years without dosage adjustment, frequency and method of administration.
Patients with Renal Impairment
Do not require daily dose adjustment, frequency or drug administration.
Patients with Hepatic Impairment
The total daily dose of 8 mg ondansetron should not be exceeded.