Tranexid 250 mg/5 ml

Indonesia • Dexa Medica

Indication

  • Fibrinolysis in menorrhagia, epistaxis, traumatic hyphema, neoplasma, obstetric complications, and other surgical procedures including bladder surgery, prostatectomy or conization of the cervix.
  • Tooth extraction in patients with hemophilia and prophylactic treatment of hereditary angioedema.

Composition

Tranexamic acid 250 mg

Package

10 ampoules of 5 ml

Dosage Forms

Injection

ATC Classification

B02A

Warning

Alcohol
Consult Your Doctor
Safety of this item for use with alcohol has not been established. Please consult your doctor.
Machinery
Consult Your Doctor
Safety of this item for use while operating heavy machinery has not been established. Please consult your doctor.
Pregnancy
Caution
This item may not be safe for use during pregnancy. Use with caution and after consultation with your doctor.
Lactation
Caution
This item may not be safe for use during lactation. Use with caution and after consultation with your doctor.

Dosage

Local Fibrinolysis

Hereditary angioneurotic edema, 500-1000 mg tranexamic acid by slow intravenous injection (maximum 100 mg/min; 2 ml/min for Tranexid 250 mg/5 ml; 1 ml/min for Tranexid 500 mg/5 ml) 3 times daily. For the treatment more than 3 days, it should be considered to use an oral tranexamic acid.

Tooth Extraction in Patients with Hemophilia

Immediately before tooth extraction:
Intravenous, 10 mg/kg of body weight.

Postsurgical:
25 mg/kg of body weight (orally) 3-4 times daily for 2-8 days (for patient unable to take medication orally, intravenous therapy, 10 mg/kg of body weight, 3-4 daily).

Postsurgical Hemorrhage

1 gram 3 times daily, slow intravenous injection, administered for the first 3 days. Therapy is then continued, using 1 gram tranexamic acid orally 3-4 times daily (starts on the fourth day after surgery until macroscopic hematuria is no longer present).

Patients with Renal Function Disorders

Serum creatinine 120-250 micromol/l (1.36-2.83 mg/dl):
IV Dose 10 mg/kg, 2 times daily.

Serum creatinine 250-500 micromol/l (2.83-5.66 mg/dl):
IV Dose 10 mg/kg, once daily.

Serum creatinine >500 micromol/l (>5.66 mg/dl):
IV Dose 10 mg/kg, every 48 hours or 5 mg/kg every 24 hours.