Tranexid 500 mg / 5 ml
- Fibrinolysis in menorrhagia, epistaxis, traumatic hyphema, neoplasma, obstetric complications, and other surgical procedures including bladder surgery, prostatectomy or conization of the cervix.
- Tooth extraction in patients with hemophilia and prophylactic treatment of hereditary angioedema.
Tranexamic acid 500 mg
Hereditary angioneurotic edema, 500-1000 mg tranexamic acid by slow intravenous injection (maximum 100 mg/min; 2 ml/min for Tranexid 250 mg/5 ml; 1 ml/min for Tranexid 500 mg/5 ml) 3 times daily. For the treatment more than 3 days, it should be considered to use an oral tranexamic acid.
Tooth Extraction in Patients with Hemophilia
Immediately before tooth extraction:
Intravenous, 10 mg/kg of body weight.
25 mg/kg of body weight (orally) 3-4 times daily for 2-8 days (for patient unable to take medication orally, intravenous therapy, 10 mg/kg of body weight, 3-4 daily).
1 gram 3 times daily, slow intravenous injection, administered for the first 3 days. Therapy is then continued, using 1 gram tranexamic acid orally 3-4 times daily (starts on the fourth day after surgery until macroscopic hematuria is no longer present).
Patients with Renal Function Disorders
Serum creatinine 120-250 micromol/l (1.36-2.83 mg/dl):
IV Dose 10 mg/kg, 2 times daily.
Serum creatinine 250-500 micromol/l (2.83-5.66 mg/dl):
IV Dose 10 mg/kg, once daily.
Serum creatinine >500 micromol/l (>5.66 mg/dl):
IV Dose 10 mg/kg, every 48 hours or 5 mg/kg every 24 hours.