Myanmar • Dexa Medica


Dexaperazon is indicated for the treatment of the following infections when caused by susceptible organisms:

  • Upper and lower respiratory tract infections
  • Upper and lower urinary tract infections
  • Peritonitis, cholecystitis, cholangitis, and others intra-abdominal infections
  • Skin and soft tissue infections

Combination therapy
Because of the broad spectrum of activity of Dexaperazon, most infections can be treated adequately with this antibiotic alone. However, Dexaperazon may be used concomitantly with other antibiotics if such combinations are indicated. If an aminoglycoside is used (see section Incompatibilities aminoglycoside), renal function should be monitored during the course of therapy (see section dosage and administration in renal dysfunction).


Cefoperazone 1 g


1 vial of 1 g

Dosage Forms

Powder for Injection

ATC Classification



Not Recommended
This item should not be used with alcohol.
Safe if Prescribed
This item is safe for use while operating heavy machinery.
Consult Your Doctor
Safety of this item for use during pregnancy has not been established. Please consult your doctor.
This item may not be safe for use during lactation. Use with caution and after consultation with your doctor.


Up to 1 Week

For neonates in the first week of life, Dexaperazon should be given every 12 hours. The maximum daily dosage of sulbactam in pediatrics should not exceed 80 mg/kg/day. For doses of Dexaperazon requiring more than 80 mg/kg/day cefoperazone activity, additional cefoperazone should be administered separately.

1 Month to 18 Years Old

Daily dosage recommendations for Dexaperazon in children are 40-80 mg/kg/day. Doses should be administered every 6 to 12 hours in equally divided doses.

In serious or refractory infections, these dosages may be increased up to 160 mg/kg/day of the 1:1 ratio. Doses should be administered in two to four equally divided doses.

18 Years Old and Above

Daily dosage recommendations for Dexaperazon in adults are 2-4 g. Doses should be administered every 12 hours in equally divided doses.

In severe or refractory infections, the daily dosage of Dexaperazon may be increased up to 8 g with the ratio 1:1 (i.e., 4 g cefoperazone activity). Patients who receive the 1:1 ratio may require additional cefoperazone administered separately. Doses should be administered every 12 hours in equally divided doses.

The recommended maximum daily dosage of sulbactam is 4 g.

Method of Administration

Dexaperazon administered by intravenous injection or infusion or intramuscular route.

Patients with Impaired Hepatic Function

Dose modification may be necessary in cases of severe biliary obstruction, severe hepatic disease or in cases of renal dysfunction coexistent with either of those conditions. In patients with hepatic dysfunction and concomitant renal impairment, cefoperazone serum concentrations should be monitored and dosage adjusted as necessary. In these cases dosage should not exceed 2 g/day of cefoperazone.

Patients with Impaired Renal Function

Dosage regimens of Dexaperazon should be adjusted in patients with marked decrease in renal function (creatinine clearance of less than 30 ml/min) to compensate for the reduced clearance of sulbactam. Dosage adjusment for Dexaperazon as follows:

  • Patients with creatinine clearances less than 15 ml/minute should receive a maximum of 500 mg of sulbactam every 12 hours (maximum daily dosage of 1 g sulbactam)
  • Patients with creatinine clearances between 15 and 30 ml/minute should receive a maximum of 1 g of sulbactam administered every 12 hours (maximum daily dosage of 2 g sulbactam)

In severe infections, it may be necessary to administer additional cefoperazone. The pharmacokinetic profile of sulbactam is significantly altered by hemodialysis. The serum half-life of cefoperazone is reduced slightly during hemodialysis. Thus, dosing should be scheduled to follow a dialysis period.