Doripenem is indicated for the treatment of the following infections in adults:
- Nosocomial pneumonia (including ventilator-associated pneumonia)
- Complicated intra-abdominal infections
- Consideration should be given to official guidance on the appropriate use of antibacterial agents
Doripenem 500 mg
0 to 18 Years Old
18 Years Old and Above
Recommended dosage and administration by infection:
Nosocomial pneumonia (including ventilator-associated pneumonia):
500 mg every 8 hours for 1 or 4 hours.
Complicated intra-abdominal infection:
500 mg every 8 hours for 1 hour.
65 Years Old and Above
No dosage adjustment is necessary in elderly patients, except in cases of moderate to severe renal insufficiency.
Method of Administration
The usual treatment duration of doripenem therapy ranges from 5-14 days and should be guided by the severity, site of the infection, and the patient’s clinical response.
Doripenem is to be reconstituted and then further diluted prior to administration by intravenous infusion over a period of 1 or 4 hours.
Patient with Renal Impairment
In patients with mild renal impairment (i.e., creatinine clearance (CrCl) is 51-79 ml/minute), no dose adjustment is necessary. In patients with moderate renal impairment (CrCl 30 to <50 ml/minute), the dose of doripenem should be 250 mg every 8 hours. In patients with severe renal impairment (CrCl <30 ml/minute), the dose of doripenem should be 250 mg every 12 hours.
Patient with Hepatic Impairment
No dose adjustment is necessary.