Tramus 50 mg / 5 ml
As an adjunct to general anesthesia to enable tracheal intubation to be performed and to relax skeletal muscles during surgery or controlled ventilation, and to facilitate mechanical ventilation in Intensive Care Unit (ICU) patients.
Atracurium 50 mg
1 Month to 18 Years Old
The dosage in children over the age of one month is similar to that in adults on a bodyweight basis.
18 to 65 Years Old
Administered by intravenous injection:
The recommended dose: 0.3-0.6 mg/kg (depending on the duration of full block required) and will provide adequate relaxation for about 15 to 35 minutes.
Endotracheal intubation can usually be accomplished within 90 seconds from the intravenous injection of 0.5 to 0.6 mg/kg. Full block can be prolonged with supplementary doses of 0.1 to 0.2 mg/kg as required. Successive supplementary dosing does not give rise to accumulation of neuromuscular blocking effect.
Administered by intravenous infusion:
After an initial bolus dose of 0.3-0.6 mg/kg, atracurium can be used to maintain neuromuscular block during long surgical procedures by administration as a continuous infusion at rates of 0.3 to 0.6 mg/kg/hour. Atracurium can be administered by infusion during cardiopulmonary bypass surgery at the recommended infusion rates.
65 Years Old and Above
Atracurium may be used at standard dosage. It is recommended, however, that the initial dose be at the lower end of the range and that it be administered slowly
Patients with Reduced Renal and/or Hepatic Function
Atracurium may be used at standard dosage at all levels of renal or hepatic function, including end stage failure.
Patients with Cardiovascular Disease
In patients with clinically significant cardiovascular disease, the initial dose of atracurium should be administered over a period of 60 seconds.
Intensive Care Unit (ICU) Patients
After an optional initial bolus dose of atracurium of 0.3 to 0.6 mg/kg, atracurium can be used to maintain neuromuscular block by administering a continuous infusion at rates of between 11 and 13 mcg/kg/minute (0.65 to 0.78 mg/kg/hour). There may be wide interpatient variability in dosage requirements and these may increase or decrease with time. Infusion rates as low as 4.5 mcg/kg/minute (0.27 mg/kg/hour) or as high as 29.5 mcg/kg/minute (1.77 mg/kg/hr) are required in some patients.
The rate of spontaneous recovery from neuromuscular block after infusion of atracurium in ICU patients is independent of the duration of administration.